In stem cell implantation, a patient's own stem cells are harvested from their bone marrow and then injected or implanted into a damaged joint. This treatment helps the damaged joint heal more effectively, preserving tissues that might otherwise sustain further damage. Because stem cell implantation can promote the healing of a damaged joint, effective treatment can reduce or even entirely eliminate the need for surgery.
Stem cells are a kind of cell called an undifferentiated cell. When a cell is undifferentiated, it means it can turn into almost any other kind of cell in the body. Depending on what kinds of chemical signals they're exposed to, stem cells can become immune system cells, bone cells, muscle cells, and other kinds of cells. Another characteristic of stem cells is that they can divide indefinitely, meaning that one stem cell can generate a virtually infinite number of new cells.
These characteristics of stem cells mean that they have the potential to be useful in a wide range of medical treatments. One way in which stem cells are being used is to heal and restore damaged joints.
Stem cells are located in moderate numbers in many of the body's tissues. In the event of an injury, stem cells in the injured area activate and differentiate into cells that are then integrated into the damaged tissue as it heals. However, the body can't always supply enough stem cells for an adequate level of healing. This is especially true as we get older, or in the event of a severe injury or progressive damage caused by a degenerative disease. These problems can be addressed with stem cell implantation, which supplies the injured area with a large number of stem cells.
The aim of stem cell treatment is to supply a damaged joint with a larger number of stem cells than the body is able to supply by natural means. In stem cell implantation, a patient's stem cells are harvested from a bone marrow sample drawn from one of the body's large bones. The stem cells may be treated in a laboratory to increase their number or make them more potent. Then the cells are injected into the area being treated, in this case a hip or knee joint.
In some cases, the cells are surgically implanted into the joint. Whether the cells are implanted or injected depends on the nature of the injury and where it's located. If the damaged part of the joint can't be easily accessed with a needle, then it might be necessary to surgically implant the cells.
There are few risks associated with stem cell transplantation, because the cells that are implanted into the joint are harvested from your own bone marrow. This means there's no risk of contracting an infectious disease from the bone marrow, or of your body rejecting the transplanted cells. However, most people do experience some mild side effects after having a stem cell transplant. For instance, it's common to have some discomfort in the treatment area for a few days.
Most people have good results with this treatment. A typical result is to have a significant reduction in pain in the affected joint within 1 to 2 months after the treatment, with continuing improvement for several more months. However, a small number of people do find that they don't get much benefit from stem cell transplantation, so it's important to have realistic expectations when you have this treatment. As well as this, because stem cell transplantation is a relatively new treatment, there is as yet little known about how long you can expect the results to last.
I am writing to thanks you & your staff fro the wonderful work you did on my hip repllacement. It is so nice not to be in constant pain and it's enjoy able to go for a walk now & not dread it as before. I can't thank you + the staff at the cavell hospital enough.
After years of arthritic pain, steroid injections, physiotherapy and arthroscopy (which actually made things far worse)... I now feel like a new woman thanks to the knee surgery you performed last month - I have no doubt this is due in no small part to your skill as a surgeon. The wound healed quickly, recovery has been rapid, without any complications and the scar is neat and beautifully stitched!!
Having recently undergone a full left knee replacement I am 100% satisfied with everything Mr Saksena and his team at The Cavell provided. I was given plenty of advice both before and after my surgery, which was very reassuring. My recovery has been rapid with minimal pain and within 8 weeks I had full extension and 130 degree flexion back in the knee. I wouldn't hesitate to recommend Mr Saksena as an orthopaedic surgeon.
I had a total knee replacement with Valgus Deformity 7 weeks ago, and this gave the surgeon extra work to do, I only have good things to say about this surgery and after care with all staff involved at Chase Farm Hospital, as in my experience I have heard a lot of good and bad things about this type of surgery, Well I can only say that if anyone has concerns about this please try not to worry it is worth while as it has given me a new lease of life to what I had before, and yes the first 2 weeks are the worse, but please do try your exercises, because as they say you only get the real benefit if you are prepared to do your bit. Thanks very much for my new lease of life yet again.
I was very fortunate to be referred to Mr Saksena as an NHS patient and was very impressed with the treatment and care provided by Mr Saksena and the whole team at Cavell Hospital. Once discharged, someone was always available to talk to you and an appointment was made immediately if you needed to see a nurse (which I did several times, due to a normal discharge from my wound). The entire staff were all friendly, cheerful and efficient. The scar is very neat and after 7 weeks I am walking well and just using a stick outdoors.
I would like to just sincerely thank you for the job you did on my knees, both of them. Before I had my knees replaced I was in constant pain, which had been the case for nearly 5 years. It was so bad that I often wondered what the use was in living! Now, nearly 2 years later, I feel I have my life back. I can now walk without pain and every single day, and I mean every single day, I walk the roads that I walked pre-operations and I remember the pain that I was in for every small distance I had to walk. Now, I walk with a smile on my face and a thrill in my heart, so very grateful for having the freedom to enjoy walking once again. I also have great fun going with the grandchildren to the park and playing with them, which before the operation was impossible as all I could do was basically sit and supervise them. So there too there is a huge change.
You did a total knee replacement on my right leg on 22nd March in the Kings Oak Hospital and it has been very successful. I am now almost pain free with the knee getting stronger each day. I would like to thank you and your excellent medical team for doing such a neat job. I would also like to thank the wonderful nurses at the hospital who were always cheerful and efficient.
In September 2014 I underwent a knee replacement operation. Mr Saksensa was an amiable professional with a calming influence and caring nature. His team were friendly and supportive. My knee replacement was a complete success and I am still enjoying my favourite sport of skiing.
You performed a partial meniscectomy at Highgate Hospital in late april. I would like to thank you for your hardwork; the problem has been entirely resolved and I am pretty sure that is down to the procedure rather than the passage of time as the condition persisted during the prior two months. Some part of that is surely down to your skill.