Platelets are a component of blood that are important for healing wounds and tissue damage. An infusion of platelet-rich plasma can help promote fast healing of certain kinds of injuries, and can help manage the joint damage caused by osteoarthritis.
Platelets are the smallest cells that circulate in the blood. They travel throughout the body via the bloodstream, circulating through arteries and veins until they're needed. When the body is injured—via a cut or scrape on the skin, for example—chemical signals travel tell platelets and other blood cells where to go in order to start the healing process. When platelets reach the site of an injury they become activated and bind to broken blood vessels in order to stop bleeding.
Platelets are also rich in proteins called growth factors. These proteins aid in healing in other ways in addition to the ability of platelets to clot the blood. For instance, some factors stimulate the growth of other cells that are involved in healing.
Platelet-rich plasma is a preparation of platelets that is made from a patient's own blood. The blood is drawn from a patient and then goes through a process that separates the platelets from the other cells in the blood. The purified platelets are then mixed with part of the original blood sample, which results in a sample with a high concentration of platelets.
The normal level for platelets in blood is between 150,000 and 450,000 platelets per microlitre. If the level of platelets circulating in the blood is too high it can potentially cause health problems, such as an increased risk of blood clots. However, injecting a platelet-rich plasma sample into an injured part of the body bypasses this problem because the injected platelets do not circulate in the blood.
While there's plenty of evidence to show that people with osteoarthritis do benefit from plate-rich injections, experts still don't know exactly how the injections work. It's likely that the platelets help by encouraging the growth of cells that stimulate the healing of damaged joints, just as they do in wound and injury healing.
If you're interested in having plate-rich plasma injections, it's important to understand that, like most treatments for osteoarthritis, they don't work in the same way for everyone. In general, it seems that a patient is more likely to benefit from the treatment if their osteoarthritis symptoms are still relatively mild.
Some people benefit more from certain treatments than other people do, and this is also true for plate-rich plasma injections. For people who do benefit from the injections, it's common to have a reduction in pain and stiffness in the treated joints, often with an improvement in joint function as well.
Platelet-rich plasma injections are a treatment that's derived from a patient's own blood, which helps to greatly reduce the variety of side effects a patient might have. For instance, there's no risk of allergic reactions to these injections, as there is with some medications.
Some people who have this treatment experience a temporary increase in pain and swelling at the injection site. This is a normal reaction, which occurs because the injection of platelets stimulates the growth of cells involved in healing. The increased number of cells at the site of injury is what causes the swelling and pain. If these side effects occur they usually last only a week or two.
I am writing to thanks you & your staff fro the wonderful work you did on my hip repllacement. It is so nice not to be in constant pain and it's enjoy able to go for a walk now & not dread it as before. I can't thank you + the staff at the cavell hospital enough.
After years of arthritic pain, steroid injections, physiotherapy and arthroscopy (which actually made things far worse)... I now feel like a new woman thanks to the knee surgery you performed last month - I have no doubt this is due in no small part to your skill as a surgeon. The wound healed quickly, recovery has been rapid, without any complications and the scar is neat and beautifully stitched!!
Having recently undergone a full left knee replacement I am 100% satisfied with everything Mr Saksena and his team at The Cavell provided. I was given plenty of advice both before and after my surgery, which was very reassuring. My recovery has been rapid with minimal pain and within 8 weeks I had full extension and 130 degree flexion back in the knee. I wouldn't hesitate to recommend Mr Saksena as an orthopaedic surgeon.
I had a total knee replacement with Valgus Deformity 7 weeks ago, and this gave the surgeon extra work to do, I only have good things to say about this surgery and after care with all staff involved at Chase Farm Hospital, as in my experience I have heard a lot of good and bad things about this type of surgery, Well I can only say that if anyone has concerns about this please try not to worry it is worth while as it has given me a new lease of life to what I had before, and yes the first 2 weeks are the worse, but please do try your exercises, because as they say you only get the real benefit if you are prepared to do your bit. Thanks very much for my new lease of life yet again.
I was very fortunate to be referred to Mr Saksena as an NHS patient and was very impressed with the treatment and care provided by Mr Saksena and the whole team at Cavell Hospital. Once discharged, someone was always available to talk to you and an appointment was made immediately if you needed to see a nurse (which I did several times, due to a normal discharge from my wound). The entire staff were all friendly, cheerful and efficient. The scar is very neat and after 7 weeks I am walking well and just using a stick outdoors.
I would like to just sincerely thank you for the job you did on my knees, both of them. Before I had my knees replaced I was in constant pain, which had been the case for nearly 5 years. It was so bad that I often wondered what the use was in living! Now, nearly 2 years later, I feel I have my life back. I can now walk without pain and every single day, and I mean every single day, I walk the roads that I walked pre-operations and I remember the pain that I was in for every small distance I had to walk. Now, I walk with a smile on my face and a thrill in my heart, so very grateful for having the freedom to enjoy walking once again. I also have great fun going with the grandchildren to the park and playing with them, which before the operation was impossible as all I could do was basically sit and supervise them. So there too there is a huge change.
You did a total knee replacement on my right leg on 22nd March in the Kings Oak Hospital and it has been very successful. I am now almost pain free with the knee getting stronger each day. I would like to thank you and your excellent medical team for doing such a neat job. I would also like to thank the wonderful nurses at the hospital who were always cheerful and efficient.
In September 2014 I underwent a knee replacement operation. Mr Saksensa was an amiable professional with a calming influence and caring nature. His team were friendly and supportive. My knee replacement was a complete success and I am still enjoying my favourite sport of skiing.
You performed a partial meniscectomy at Highgate Hospital in late april. I would like to thank you for your hardwork; the problem has been entirely resolved and I am pretty sure that is down to the procedure rather than the passage of time as the condition persisted during the prior two months. Some part of that is surely down to your skill.