Blood is made up of many different components, including several kinds of cells and proteins. One important component of blood is platelets, which promote healing of wounds and injuries. Concentrated injections of platelets, when injected into damaged joints, can help promote healing, prevent further damage, and even reduce or eliminate the need for surgical joint repair or replacement.
Platelets are the smallest cells in the blood, and constantly circulate in the bloodstream until they're needed. When the body sustains an injury, such as a cut, the damaged tissue sends out chemical signals that tell platelets and other cells where the injury is located. In response to these chemical signals, platelets travel via the bloodstream to the site of the injury. Once there they become activated, changing their shape and binding to the edges of broken blood vessels. This is how a clot forms, as the binding of the platelets is one thing that helps to stop bleeding.
Another way platelets promote healing is by releasing proteins called growth factors at sites where tissue has been damaged. These proteins do various things that help to heal wounded tissue; for instance, some growth factors activate other kinds of cells involved in healing, such as stem cells.
Platelet-rich plasma injections promote healing of damaged joints, and work to preserve joint tissue, in a similar fashion. However, because the injections contain a much higher concentration of platelets than normal untreated blood, the healing effect is more intense and more effective than usual.
Everyone reacts differently to platelet-rich plasma treatments, but most people do benefit from reduced joint pain and stiffness. The platelet treatments help stimulate healing of the damaged joint tissue, which in turn helps to prevent irreversible degenerative damage and preserve joint structure and function. If a joint disease or injury is treated effectively with platelet-rich plasma injections, it's even possible to reduce or eliminate the need for surgery.
Platelet-rich plasma is made from a patient's own blood. To make platelet-rich plasma a blood sample is drawn from a patient. The blood is then treated to separate out the platelets from the other components in the blood, and then mixed with a small amount of the patient's whole blood. This process results in a preparation that contains a much higher concentration of platelets than normal. The final step is to inject the platelet-rich preparation into the damaged joint. In total, the entire procedure—from drawing blood to injecting platelet-rich plasma—takes a couple of hours.
Normal blood typically contains between 150,000 and 450,000 platelets per microlitre, whereas platelet-rich plasma contains up to 5 times as many platelets per microlitre. Having an excessive number of platelets circulating in the bloodstream is potentially dangerous, as it can promote the formation of blood clots. However, this risk doesn't exist with platelet-rich plasma injections. This is because the platelets that are injected stay at the site of injection, and don't circulate in the bloodstream.
Because platelet-rich plasma is a treatment that uses a patient's own blood, there are few risks and side effects associated with the treatment. For instance, there's no risk of contracting an infection from the blood, and no risk of an allergic reaction. One of the most common side effects is that some people have a temporary increase in pain or swelling at the site of injection, due to the increased number of healing-promoting cells there. This is a normal reaction that usually lasts only 1 to 2 weeks.
I am writing to thanks you & your staff fro the wonderful work you did on my hip repllacement. It is so nice not to be in constant pain and it's enjoy able to go for a walk now & not dread it as before. I can't thank you + the staff at the cavell hospital enough.
After years of arthritic pain, steroid injections, physiotherapy and arthroscopy (which actually made things far worse)... I now feel like a new woman thanks to the knee surgery you performed last month - I have no doubt this is due in no small part to your skill as a surgeon. The wound healed quickly, recovery has been rapid, without any complications and the scar is neat and beautifully stitched!!
Having recently undergone a full left knee replacement I am 100% satisfied with everything Mr Saksena and his team at The Cavell provided. I was given plenty of advice both before and after my surgery, which was very reassuring. My recovery has been rapid with minimal pain and within 8 weeks I had full extension and 130 degree flexion back in the knee. I wouldn't hesitate to recommend Mr Saksena as an orthopaedic surgeon.
I had a total knee replacement with Valgus Deformity 7 weeks ago, and this gave the surgeon extra work to do, I only have good things to say about this surgery and after care with all staff involved at Chase Farm Hospital, as in my experience I have heard a lot of good and bad things about this type of surgery, Well I can only say that if anyone has concerns about this please try not to worry it is worth while as it has given me a new lease of life to what I had before, and yes the first 2 weeks are the worse, but please do try your exercises, because as they say you only get the real benefit if you are prepared to do your bit. Thanks very much for my new lease of life yet again.
I was very fortunate to be referred to Mr Saksena as an NHS patient and was very impressed with the treatment and care provided by Mr Saksena and the whole team at Cavell Hospital. Once discharged, someone was always available to talk to you and an appointment was made immediately if you needed to see a nurse (which I did several times, due to a normal discharge from my wound). The entire staff were all friendly, cheerful and efficient. The scar is very neat and after 7 weeks I am walking well and just using a stick outdoors.
I would like to just sincerely thank you for the job you did on my knees, both of them. Before I had my knees replaced I was in constant pain, which had been the case for nearly 5 years. It was so bad that I often wondered what the use was in living! Now, nearly 2 years later, I feel I have my life back. I can now walk without pain and every single day, and I mean every single day, I walk the roads that I walked pre-operations and I remember the pain that I was in for every small distance I had to walk. Now, I walk with a smile on my face and a thrill in my heart, so very grateful for having the freedom to enjoy walking once again. I also have great fun going with the grandchildren to the park and playing with them, which before the operation was impossible as all I could do was basically sit and supervise them. So there too there is a huge change.
You did a total knee replacement on my right leg on 22nd March in the Kings Oak Hospital and it has been very successful. I am now almost pain free with the knee getting stronger each day. I would like to thank you and your excellent medical team for doing such a neat job. I would also like to thank the wonderful nurses at the hospital who were always cheerful and efficient.
In September 2014 I underwent a knee replacement operation. Mr Saksensa was an amiable professional with a calming influence and caring nature. His team were friendly and supportive. My knee replacement was a complete success and I am still enjoying my favourite sport of skiing.
You performed a partial meniscectomy at Highgate Hospital in late april. I would like to thank you for your hardwork; the problem has been entirely resolved and I am pretty sure that is down to the procedure rather than the passage of time as the condition persisted during the prior two months. Some part of that is surely down to your skill.